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These are documented research distinctions, not interchangeable substitutions

Suboptimal means the levels are not optimal

It includes pathologies that cause an acute illness with severe thyroid pain (e.g., subacute thyroiditis and infectious thyroiditis) as well as conditions in which there is no clinically evident inflammation and the manifestations primarily reflect thyroid dysfunction or a goiter (e.g., painless thyroiditis and fibrous Riedels thyroiditis)

In the cleavable linker domain, research has shifted toward multi-trigger mechanisms (e.g., responding to both enzymatic and pH changes) to enhance tumor specificity